Myroslava Romach Karen Parker

OXFORD HOUSE See Treatment Programs/Centers/Organizations: An Historical Perspective

OXYCODONE Oxycodone is one of the most widely used OPIOID ANALGESICS in the United States, and it is usually used in conjunction with the analgesics aspirin or acetominophen. The combinations have proven effective and are, in some ways, superior to oxycodone alone, since they permit a lower dose of the opioid—and are therefore less likely to produce constipation, drowsiness, and nausea. Oxycodone is a derivative of OXYMOR-PHONE, the relationship being the same as that between Codeine and Morphine. Like codeine, oxycodone is metabolized to oxymorphone, which is assumed to be responsible for its activity. Pharmacologically, the actions of oxycodone and oxymorphone are quite similar to those of morphine, so toxicity and ADDICTION can occur.

BIBLIOGRAPHY

JAFFE, J. H., & MARTIN, W. R. (1990). Opioid analgesics and antagonists. In A. G. Gilman et al. (Eds.), (1990). Goodman and Gilman's the pharmacological basis of therapeutics, 8th ed. New York: Pergamon.

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