The use of one type of drug may lead to experimenting with other drugs as users add to or find substitutes for their original drug of choice. Some of this progression may be an effect of maturation—that is, of drug-using adolescents moving on to other drugs as they grow older—or it may be attributable to the cost and availability of different types of drugs, introduction to new substances by drug-using peers, or drug-seeking behavior in which individuals continue trying different drugs until they achieve the desired effect. Polydrug (multiple-drug) use can also occur when people try to counteract the effect of one drug by the use of another—for example, by taking tranquilizers (which relieve symptoms of anxiety) in order to counteract the anxiety-producing effects of cocaine.

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