Michael J Kuhar

ANTIPSYCHOTIC Any of a group of drugs, also termed neuroleptics, used medicinally in the therapy of schizophrenia, organic psychoses, the manic phase of manic-depressive illness, and other acute psychotic illnesses. The prototype antipsychotics are the phenothiazines, such as chlorpro-mazine (Thorazine), and the butyrophenones such as haloperidol (Haldol). The antipsychotics are tricyclic compounds, with chemical substitution at R1 and R2, which determine the selectivity and potency of the neuroleptic.

Figure 1


The ''positive'' symptoms of psychotic disorders, such as hallucinations, can often be effectively treated with antipsychotics; the ''negative'' symptoms, such as withdrawal, are less effectively managed by these drugs. Most of these drugs also have effects on movement, and a good response to the drugs' antipsychotic effects must often be balanced against motor side effects.

ANTI-SALOON LEAGUE See Temperance Movement; Women's Christian Temperance Movement

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