Ivan Izquierdo James L Mcgaugh

MEPERIDINE Meperidine is a totally synthetic OPIOID analgesic (painkiller) with a structure quite distinct from MORPHINE, a natural OPIATE. Unlike morphine's rigid fused ring structures, the structure of meperidine is flexible; it is a phe-nylpiperidine and bends so that the key portions of the molecule can assume positions similar to those of morphine. A number of other compounds with similar structures are widely used in medicine, including loperamide (used primarily for treating diarrhea) and the extraordinarily potent ANALGESIC agents fentanyl, sufentanil, lofentanil, and alfentanil (for treating PAIN).

Meperidine is a compound with strong analgesic effects similar to morphine's, although greater amounts are needed to produce the same level of analgesia. It is one of the more commonly prescribed opioid analgesics and is better known under one of its brand names, Demerol. Given by injection, 100 milligrams of meperidine equals 10 milligrams of morphine. Meperidine can be administered orally as well as by injection but its potency it not as great following oral administration, so the dose must be increased proportionally. Like morphine, continued use of meperidine is associated with decreased analgesia—TOLERANCE—as well as Physical Dependence. As with the other opioids, ADDICTION (defined as a drug-seeking behavior) is not commonly observed with this drug when used for medicinal purposes, but meperidine is highly

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