This is the state of functional impairment resulting from the actions of a drug. It may be acute, i.e., caused by consumption of a high dose of drug on one occasion; it may be chronic, i.e., caused by repeated use of large enough doses to maintain an excessive drug concentration in the body over a long period of time. The characteristic pattern of intoxication varies from one drug to another, depending upon the mechanisms of action of the different substances. For example, intoxication by alcohol or barbiturates typically includes disturbances of neuromuscular coordination, speech, sensory functions, memory, reaction time, reflexes, judgment of speeds and distances, and appropriate control of emotional expression and behavior. In contrast, intoxication by amphetamine or cocaine usually includes raised blood pressure and heart rate, elevation of body temperature, intense hyperactivity, mental disturbances such as hallucinations and paranoid delusions, and sometimes convulsions. The term may be considered equivalent to overdosage, in that the signs of intoxication usually arise at higher doses than the pleasurable subjective effects for which the drug is usually taken.

Drug Addiction

Drug Addiction

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