Glueglue Sniffing See Inhalants

GLUTAMATE Glutamate (GLU) is a dicar-boxylic aliphatic amino acid. Chemically symbolized as COOH-CH2-CH2[NH2]-COOH, it is abundant (micromolar concentrations/mg protein) in NEURONS (nerve cells) as well as in almost all other cells of the body. Its role as the major excitatory Neurotransmitter in the brain was recognized reluctantly; its universal ability to excite all neurons was considered too nonspecific for a neuro-transmitter, so it awaited the development of drugs that antagonized GLU and the specific neuro-pathways from which it was released.

Its source for this special role in NEUROTRANSMISSION is unknown, but the synaptic vesicles of glutamatergic neurons have a selective ion-ex change mechanism to compartmentalize GLU from other metabolic pathways. Excessive GLU-receptor activation can lead to neuronal death.

(See ALSO: Research)

BIBLIOGRAPHY

Cooper, J. R., Bloom, F. E., & Roth, R. H. (1991). The biochemical basis of neuropharmacology, 6th ed. New York: Oxford University Press.

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