Effectiveness Of Abuseliability Testing

Because of the availability of procedures for abuse-liability testing in humans, it seems reasonable to ask how well they work. That is, has it been possible to predict from the results of these tests whether a new drug will be abused when it becomes generally available? The two major sources available for checking the effectiveness of human abuse-liability testing procedures are case reports by clinicians of patient drug abuse, and EPIDEMIOLOGICAL surveys of large numbers of individuals as well as of specific target sites (e.g., hospital emergency rooms). Both of these approaches have many shortcomings, since they lack the precision and focus that human laboratory testing can provide. But despite the draw-backs, they can detect abuse-liability problems in both specific groups of individuals and the population at large, in a manner that has generally validated the results of human laboratory-testing procedures.

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