Dysphoria Delusions And Hallucinations

It is rare for morphine-like analgesics to produce psychotic reactions. In patients with severe pain and discomfort and in opiate addicts, single doses of morphine-like drugs most commonly produce feelings of well-being. In normal subjects with no pain or with only modest levels of discomfort, morphine produces feelings of apathy and enervation, which are somewhat dysphoric. The drug ¿-propoxyphene (Darvon) has been reported to produce bizarre reactions—delusions and hallucinations—particularly when taken chronically in large doses and when used to suppress opioid absti nence. Some agonists-antagonists (e.g., pentazocine [Talwin], nalorphine, and cyclazocine) produce feelings of apathetic sedation, perceptual distortions, anxiety, delusion, and hallucinations.

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