Drugmetabolizing Enzymes

Drug-metabolizing enzymes change the chemical nature of drugs by inserting oxygen, hydrogen, water, or small molecules such as amino acids and sugar molecules. The resulting metabolites may thus contain hydroxyl (the univalent group or ion OH), or hydrogenated or hydrolysis products, or be conjugated with sugar or other functional groups. By far the most commonly occurring metabolic step is hydroxylation (the addition of oxygen) by the enzyme oxygenase—and this will be discussed in detail.

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Drug Free Life

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