Amobarbital may be given orally, intramuscularly, or intravenously for the treatment of insomnia or anxiety. The adult dosage for sedation is 15 to 50 milligrams but 65 to 200 milligrams for sleep. For treating convulsions, the adult dose is 65 to 200 milligrams, with a maximum dose of 500 milligrams.
Amobarbital should not be given to patients with a history of addiction; personal or family history of porphyria; severe kidney, liver, or lung disease; or hypersensitivity to barbiturates.
Amobarbital is incompatible with a number of medications, including dimenhydrinate, phenyt-oin, hydrocortisone, insulin, morphine, cimetidine, pancuronium, streptomycin, tetracycline, vancomycin, and penicillin G. It may decrease the effectiveness of birth control pills containing estrogen. It has also been shown to increase the risk of birth defects if taken during pregnancy.
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