Dopamine And

Although most abused drugs lower the threshold for ICS for some drugs, the findings have not always been consistent, particularly with Hallucinogens and the Sedative-Hypnotics, including Alcohol (ethanol). For the most part, the threshold-lowering effects caused by the abused substances are compatible with the hypothesis that facilitation of Dopamine is involved in their rewarding effects. Drugs that increase dopamine availability at the synapse facilitate ICS, and those that block dopamine transmission decrease ICS (i.e., they raise the threshold—or the amount of current—needed to produce rewarding effects).

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