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Figure 2

Substituted Phenethylamines some of their effects involve interactions with systems that use these neurotransmitters. DOM, MDA, and MDMA are synthesized compounds that have structural similarities to the psychostimulant AMPHETAMINE. Thus, they also have some stimulant properties aside from their hallucinogenic activity. They have inaccurately been called psychotomi-metic amphetamines, and they are sometimes referred to as stimulant-hallucinogens. It should be pointed out that there are literally hundreds of analogs of the above compounds that have been synthesized and sometimes are found on the street, the so-called DESIGNER DRUGS.

The overall psychological effects of the hallucinogens are quite similar—but the rate of onset, duration of action, and absolute intensity of the effects can differ. As the various hallucinogens differ widely in potency and in the duration of their effects, some of the apparent qualitative differences between hallucinogens may be due, at least in part, to the amount of drug ingested. Aside from their behavioral effects, the hallucinogens also possess significant autonomic activity, meaning that they can affect the sympathetic and parasympathetic nervous systems. The autonomic effects can include marked pupillary dilation and exaggerated reflexes. There may be increases in blood pressure, heart rate, and body temperature. Some of the hallucinogens may initially cause nausea. These autonomic effects of the hallucinogens are variable and may be due, at least in part, to the anxiety state

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