Clinical Consequences

Drug metabolites are often pharmacologically less active than the parent drug. Yet some biotransformation products are active—for example CODEINE is relatively inactive but is metabolized to the active drug MORPHINE. Because the liver is the major site of drug metabolism, acute or chronic liver diseases would alter drug metabolism, resulting in prolonged drug half-lives and effects.

(SEE ALSO: Complications: Liver (Alcohol); Drug Interaction and the Brain; Drug Interactions and Alcohol )

BIBLIOGRAPHY

JAKOBY, W. B. (Ed.). (1980). Enzymatic basis of detoxication. New York: Academic Press. Kalow, W. (Ed.). (1992). Pharmacogenetics of drug metabolism. New York: Pergamon. KATSUNG, B. G. (Ed.). (1992). Basic and clinical pharmacology, 5th edition. Norwalk, CT: Appleton & Lange.

Ted Inaba Revised by Mary Carvlin

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